Guido M E, Rusak B, Robertson H A
Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada.
Brain Res. 1996 Sep 2;732(1-2):215-22. doi: 10.1016/0006-8993(96)00526-4.
We examined both spontaneous and light-evoked expression of junB mRNA in the hamster suprachiasmatic nucleus (SCN), an endogenous circadian pacemaker. junB was expressed in the SCN in response to a light pulse during the subjective night and early subjective day as well as spontaneously during the transition from subjective night to subjective day. Light-evoked expression was strongest in the ventral SCN, while spontaneous expression was stronger in the dorsal SCN. Spontaneous expression began around subjective dawn and persisted for at least 4 h into the subjective day. The expression of junB mRNA may play a role in both phase-shifting responses to light and in spontaneous oscillation of the SCN pacemaker.
我们研究了仓鼠视交叉上核（SCN，一种内源性昼夜节律起搏器）中junB mRNA的自发表达和光诱发表达。在主观夜间和主观日早期，视交叉上核会响应光脉冲而表达junB，并且在从主观夜间向主观日过渡期间也会自发表达。光诱发表达在腹侧视交叉上核中最强，而自发表达在背侧视交叉上核中更强。自发表达在主观黎明左右开始，并在主观日持续至少4小时。junB mRNA的表达可能在对光的相位转移反应以及视交叉上核起搏器的自发振荡中都发挥作用。
