Mima T, Terada K, Maekawa M, Nagamine T, Ikeda A, Shibasaki H
Department of Brain Pathophysiology, Kyoto University School of Medicine, Japan.
Exp Brain Res. 1996 Sep;111(2):233-45. doi: 10.1007/BF00227300.
Brisk passive flexion of the proximal interphalangeal joint of the middle finger, produced by using a newly devised instrument, elicited evoked potentials on the scalp. The present study carefully excluded the possible contribution of sensory modalities other than proprioception. The initial part of cortical response was a positive deflexion at the contralateral central area (P1 at 34.6 ms after the stimulus). This was followed by a midfrontal negative wave (N1 at 44.8 ms) and a clear positivity at the contralateral centroparietal area (P2 at 48.0 ms). The evoked responses persisted in spite of the abolition of cutaneous and joint afferents of the finger caused by ischemic anesthesia, but they were lost by ischemic anesthesia of the forearm. Thus, the cortical evoked responses obtained in this study most probably reflect muscle afferent inputs. The scalp distribution of P1 suggested that its cortical generator source was different from that of the N20-P20 components of evoked potentials to electrical median nerve stimulation. Brodmann areas 2 and 3a of human brain, which are known to receive deep receptor inputs, are the most plausible generator sites for the early components of the proprioception-related evoked responses. The amplitude of P2 was related to the velocity but not to the magnitude of movement. In conclusion, the present study established a method for recording the evoked responses to the brisk passive movement of the finger joint, which mainly reflect the dynamic aspects of proprioception mediated through muscle afferent.
使用一种新设计的仪器对中指近端指间关节进行快速被动屈曲，可在头皮上引出诱发电位。本研究仔细排除了本体感觉以外的其他感觉模态的可能影响。皮层反应的初始部分是对侧中央区的正向偏转（刺激后34.6毫秒出现P1）。随后是额中部负波（44.8毫秒出现N1）和对侧中央顶叶区的明显正向波（48.0毫秒出现P2）。尽管缺血性麻醉导致手指的皮肤和关节传入神经被阻断，但诱发电反应仍然存在，但在前臂缺血性麻醉后消失。因此，本研究中获得的皮层诱发电反应很可能反映了肌肉传入输入。P1的头皮分布表明其皮层起源与正中神经电刺激诱发电位的N20 - P20成分不同。已知接受深部感受器输入的人类大脑布罗德曼2区和3a区是本体感觉相关诱发电反应早期成分最可能的起源部位。P2的波幅与运动速度有关，而与运动幅度无关。总之，本研究建立了一种记录手指关节快速被动运动诱发电反应的方法，该反应主要反映通过肌肉传入介导的本体感觉的动态方面。
