Mima T, Ikeda A, Terada K, Yazawa S, Mikuni N, Kunieda T, Taki W, Kimura J, Shibasaki H
Department of Brain Pathophysiology, Kyoto University School of Medicine, Japan.
Electroencephalogr Clin Neurophysiol. 1997 Mar;104(2):103-7. doi: 10.1016/s0168-5597(96)96142-0.
Modality specificity of human primary somatosensory cortex was studied by recording somatosensory evoked potentials (SEPs) from subdural electrodes in a patient with intractable focal motor seizure. A newly developed device was used for selectively activating proprioception. The spatial and temporal distributions of proprioception-related SEPs elicited by brisk passive flexion movement at the proximal interphalangeal (PIP) joint of the middle finger (4 degrees in 25 ms) were quite different from those to cutaneous sense evoked by electric stimulation of the digital nerve at the same site. It was for the first time demonstrated that proprioception-related SEPs following passive finger movement do not originate in area 3b, which was clearly activated by cutaneous stimulation, and that other sites at the sensorimotor cortex such as areas 2, 3a and 4 possibly contribute to the cortical processing of proprioception.
通过记录一名患有顽固性局灶性运动性癫痫患者硬膜下电极的体感诱发电位（SEP），研究了人类初级体感皮层的模态特异性。使用一种新开发的装置选择性激活本体感觉。在中指近端指间关节（PIP）进行轻快被动屈曲运动（25毫秒内4度）所诱发的与本体感觉相关的SEP的空间和时间分布，与在同一部位通过数字神经电刺激诱发的皮肤感觉的分布有很大不同。首次证明，被动手指运动后与本体感觉相关的SEP并非起源于3b区，而皮肤刺激可明显激活该区，并且感觉运动皮层的其他部位，如2区、3a区和4区可能参与了本体感觉的皮层处理。
