Coogan P F, Clapp R W, Newcomb P A, Mittendorf R, Bogdan G, Baron J A, Longnecker M P
Department of Environmental Health, Boston University School of Public Health, Massachusetts, USA.
Am J Ind Med. 1996 Oct;30(4):430-7. doi: 10.1002/(SICI)1097-0274(199610)30:4<430::AID-AJIM8>3.0.CO;2-Z.
Data from a population-based case control study were used to estimate occupation-specific relative risks for female breast cancer, adjusted for established breast cancer risk factors. Breast cancer cases under age 75 were identified from tumor registries in four states. Controls were randomly selected from driver's license and Medicare beneficiary lists. Information on usual occupation and risk factors was obtained by telephone interview. Odds ratios from logistic regression adjusted for age, state, body mass index, benign breast disease, family history of breast cancer, menopausal status, age at menarche, parity, age of first birth, lactation history, education, and alcohol consumption were calculated for each of 26 occupational groups. Complete occupational information was obtained for 6,835 cases and 9,453 controls. Of 26 occupational groups, only "administrative support occupations" had a statistically significantly increased risk of breast cancer (OR = 1.15, 95% CI 1.06-1.24). In these data, no specific occupational group had an unusual risk of breast cancer. Increased risks reported elsewhere for nurses and teachers were not corroborated.
一项基于人群的病例对照研究的数据被用于估计女性乳腺癌特定职业的相对风险，并针对已确定的乳腺癌风险因素进行了调整。75岁以下的乳腺癌病例是从四个州的肿瘤登记处识别出来的。对照是从驾照和医疗保险受益人名单中随机选取的。通过电话访谈获取了关于通常职业和风险因素的信息。针对26个职业组中的每一组，计算了经年龄、州、体重指数、良性乳腺疾病、乳腺癌家族史、绝经状态、初潮年龄、产次、首次生育年龄、哺乳史、教育程度和饮酒情况调整后的逻辑回归比值比。获得了6835例病例和9453例对照的完整职业信息。在26个职业组中，只有“行政支持职业”患乳腺癌的风险有统计学显著增加（比值比=1.15，95%置信区间1.06 - 1.24）。在这些数据中，没有特定职业组有异常的乳腺癌风险。其他地方报道的护士和教师的风险增加并未得到证实。
