呼肠孤病毒非结构蛋白sigma1NS可被小鼠细胞毒性T淋巴细胞识别。
The reovirus nonstructural protein sigma1NS is recognized by murine cytotoxic T lymphocytes.
作者信息
Hoffman L M, Hogan K T, Cashdollar L W
机构信息
Department of Microbiology, Medical College of Wisconsin, Milwaukee 53226, USA.
出版信息
J Virol. 1996 Nov;70(11):8160-4. doi: 10.1128/JVI.70.11.8160-8164.1996.
Abstract
The cytotoxic T-lymphocyte (CTL) response in reovirus-infected C3H mice was investigated by using reovirus-vaccinia virus recombinants. Results of cytotoxicity assays indicated that the nonstructural protein sigma1NS elicited a significant CTL response. Experiments with sigma1NS-specific CTL lines showed that both strain-specific and cross-reactive epitopes exist in the sigma1NS protein.
摘要
利用呼肠孤病毒-痘苗病毒重组体研究了呼肠孤病毒感染的C3H小鼠中的细胞毒性T淋巴细胞（CTL）反应。细胞毒性试验结果表明，非结构蛋白sigma1NS引发了显著的CTL反应。对sigma1NS特异性CTL系的实验表明，sigma1NS蛋白中存在菌株特异性和交叉反应性表位。
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