Finberg R, Spriggs D R, Fields B N
J Immunol. 1982 Nov;129(5):2235-8.
Previous studies have demonstrated the importance of the hemagglutinin (HA) of reovirus in determining virus-specific immune responses. In this study, we have used anti-HA monoclonal antibodies and reoviruses with antigenically altered HA proteins to further analyze the CTL response against the HA. We showed that reovirus-specific CTL primarily recognize one distinct antigenic domain on the HA. These results emphasize the fine specificity of the T cell receptor that recognizes viral determinants. The CTL response is directed against the region of the HA that is also responsible for neurotropism and binding to neutralizing antibody.
先前的研究已经证明呼肠孤病毒的血凝素（HA）在决定病毒特异性免疫反应方面的重要性。在本研究中，我们使用了抗HA单克隆抗体和具有抗原性改变的HA蛋白的呼肠孤病毒，以进一步分析针对HA的细胞毒性T淋巴细胞（CTL）反应。我们发现呼肠孤病毒特异性CTL主要识别HA上一个独特的抗原结构域。这些结果强调了识别病毒决定簇的T细胞受体的精细特异性。CTL反应针对的是HA中也负责嗜神经性和与中和抗体结合的区域。
