牛病毒性腹泻病毒：一种具有两个内部缺失的细胞病变性缺陷干扰颗粒的特性
Bovine viral diarrhea virus: characterization of a cytopathogenic defective interfering particle with two internal deletions.
作者信息
Kupfermann H, Thiel H J, Dubovi E J, Meyers G
机构信息
Department of Clinical Virology, Federal Research Centre for Virus Diseases of Animals, Tübingen, Germany.
出版信息
J Virol. 1996 Nov;70(11):8175-81. doi: 10.1128/JVI.70.11.8175-8181.1996.
Abstract
Molecular characterization of bovine viral diarrhea virus pair 13 revealed that isolate CP13 is composed of a cytopathogenic (cp) defective interfering particle (DI13) and a noncytopathogenic (noncp) helper virus. The DI13 genome possesses two internal deletions of 1,611 and 3,102 nucleotides. Except for a small fragment of the gene coding for glycoprotein E1, all structural protein genes are deleted together with most of the Npro gene, the region coding for nonstructural proteins p7 and NS2. While the amino terminus of NS3 seems to be strictly conserved for all other cp bovine viral diarrhea viruses, NS3 of DI13 is amino-terminally truncated and fused to 23 amino acids derived from Npro and E1. Characterization of the DI-helper virus system revealed a striking discrepancy between RNA production and generation of infectious viruses.
摘要
牛病毒性腹泻病毒13型的分子特征表明，分离株CP13由细胞病变性（cp）缺陷干扰颗粒（DI13）和非细胞病变性（noncp）辅助病毒组成。DI13基因组存在两个分别为1611和3102个核苷酸的内部缺失。除了编码糖蛋白E1的基因的一小段片段外，所有结构蛋白基因以及大部分Npro基因、编码非结构蛋白p7和NS2的区域都被删除。虽然NS3的氨基末端对于所有其他细胞病变性牛病毒性腹泻病毒似乎严格保守，但DI13的NS3在氨基末端被截短并与来自Npro和E1的23个氨基酸融合。对DI-辅助病毒系统的特征分析揭示了RNA产生与感染性病毒产生之间的显著差异。
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