Sorrell M, Rosen J F
Arch Environ Health. 1977 Jul-Aug;32(4):160-4. doi: 10.1080/00039896.1977.10667274.
This study was undertaken to evaluate relationships between blood or serum levels of lead (Pb), calcium, and 25-hydroxyvitamin D (25-OHD), within the framework of a nutritional survey of lead-burdened children. The results demonstrate that: regardless of blood Pb concentration and season of the year, serum 25-OHD concentration reflects vitamin D intake; high blood Pb (greater than or equal to 60 microgram/dl) was associated with decreased levels of 25-OHD (18+/--1 ng/ml vs. 32+/- in controls, P less than .001); concentrations Pb and calcium were inversely correlated in control and lead-burdened children; and children in the high blood Pb group (greater than or equal to 60 microgram/dl) had lower mean daily intakes of both calcium (610 +/- 20 mg vs. 770 +/- 20 in controls, P less than .001) and vitamin D (210 +/- 17 IU vs. 325 +/- 20 in controls, P less than .001). These data indicate that, in Pb-burdened children, multiple factors modify the absorption and toxicity of Pb, and relative vitamin D deficiency, not excess, is associated with high blood Pb levels. Assessment of nutrition, calcium metabolism, and vitamin D status is recommended in evaluating children known to have undue absorption of Pb.
本研究旨在评估在对铅负荷过高儿童进行营养调查的框架内，血液或血清中铅（Pb）、钙和25-羟基维生素D（25-OHD）水平之间的关系。结果表明：无论血液中铅浓度和一年中的季节如何，血清25-OHD浓度都反映维生素D的摄入量；高血铅（大于或等于60微克/分升）与25-OHD水平降低有关（对照组为32±，铅负荷过高儿童组为18±1纳克/毫升，P＜0.001）；在对照组和铅负荷过高儿童中，铅浓度和钙浓度呈负相关；高血铅组（大于或等于60微克/分升）儿童的钙平均每日摄入量（对照组为770±20毫克，该组为610±20毫克，P＜0.001）和维生素D平均每日摄入量（对照组为325±20国际单位，该组为210±17国际单位，P＜0.001）均较低。这些数据表明，在铅负荷过高的儿童中，多种因素会改变铅的吸收和毒性，相对维生素D缺乏而非过量与高血铅水平有关。建议在评估已知有铅过度吸收的儿童时，对其营养状况、钙代谢和维生素D状态进行评估。
