Krishnan R, Shankaran S, Krishnan M, Kauffman R E, Kumar P, Lucena J
Department of Pediatrics, Children's Hospital of Michigan, Detroit 48201, USA
Biol Neonate. 1996;70(3):135-40. doi: 10.1159/000244358.
The pharmacokinetics of recombinant human erythropoietin was studied in 12 very low birth weight preterm infants < 32 weeks of gestation after subcutaneous administration of 300 IU/kg at a postconceptional age of 34 (32-37) weeks and a weight of 1,505 (1330-1,740)g (median and range). The administration of recombinant human erythropoietin produced a rapid increase in serum erythropoietin levels with a peak level of 362.8 mIU/ml at 8.9 h. The area under the curve was 8,177.5 (4,597.1-15,453.0) mIU/ml/h, the absorption half-life was 5.5 (1.6-6.6) h, the elimination half-life was 7.9 (5.6-19.4) h, and the residence time was 19.6 (5.1-32.6) h (all values reflect median and range). There was no significant correlation between absorption and elimination half-life of erythropoietin and birth weight, gestational age, sex, and age and weight of the infants at the time of administration of erythropoietin. Based on absorption and elimination kinetics, the dosing interval for subcutaneous administration must not be < 48 h.
在12例孕龄小于32周的极低出生体重早产儿中研究了重组人促红细胞生成素的药代动力学。这些早产儿在孕龄34（32 - 37）周、体重1505（1330 - 1740）g（中位数及范围）时皮下注射300 IU/kg重组人促红细胞生成素。注射重组人促红细胞生成素后血清促红细胞生成素水平迅速升高，8.9小时时达到峰值362.8 mIU/ml。曲线下面积为8177.5（4597.1 - 15453.0）mIU/ml/h，吸收半衰期为5.5（1.6 - 6.6）小时，消除半衰期为7.9（5.6 - 19.4）小时，驻留时间为19.6（5.1 - 32.6）小时（所有数值均反映中位数及范围）。促红细胞生成素的吸收半衰期和消除半衰期与出生体重、孕龄、性别以及注射促红细胞生成素时婴儿的年龄和体重之间无显著相关性。基于吸收和消除动力学，皮下给药的给药间隔不得小于48小时。
