免疫功能正常宿主中的单纯疱疹病毒所致慢性脑膜炎。

Chronic meningitis due to herpes simplex virus in an immunocompetent host.

作者信息

Chin R H, Ross B C, Taylor K I, Yung A P, Johnson P D

机构信息

Fairfield Infectious Diseases Hospital, Victoria, Australia.

出版信息

Eur J Clin Microbiol Infect Dis. 1996 Aug;15(8):650-3. doi: 10.1007/BF01691151.

DOI:10.1007/BF01691151

PMID:8894573

Abstract

Herpes simplex virus (HSV) typically causes mucocutaneous disease, encephalitis, and acute men ingitis. There have been no previous reports of chronic meningitis due to this virus. A case of chronic meningitis due to herpes simplex virus type 2 (HSV-2) in a previously healthy 35-year-old woman whose predominant symptoms were headache and meningism without fever is described. Analysis of cerebrospinal fluid (CSF) revealed a lymphocytic pleocytosis, elevated protein, and hypoglycorrhachia. The diagnosis of herpes simplex meningitis was supported by the detection of HSV-2 DNA in CSF by polymerase chain reaction and by intrathecal production of HSV-specific antibody. The patient recovered after treatment with intravenous acyclovir and glucocorticoids.

摘要

单纯疱疹病毒（HSV）通常引起黏膜皮肤疾病、脑炎和急性脑膜炎。此前尚无该病毒导致慢性脑膜炎的报道。本文描述了一例由2型单纯疱疹病毒（HSV-2）引起的慢性脑膜炎病例，患者为一名35岁既往健康的女性，主要症状为头痛和颈项强直，无发热。脑脊液（CSF）分析显示淋巴细胞增多、蛋白升高和脑脊液低糖。聚合酶链反应检测脑脊液中HSV-2 DNA以及鞘内产生HSV特异性抗体支持单纯疱疹性脑膜炎的诊断。患者经静脉注射阿昔洛韦和糖皮质激素治疗后康复。