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俄罗斯圣彼得堡男性中血管紧张素转换酶基因多态性与临界高血压之间无关联。

Absence of association between the angiotensin-converting enzyme gene polymorphism and borderline hypertension in men of St Petersburg, Russia.

作者信息

Popov V, Fomicheva E, Kovalev J, Schwartz E

机构信息

St Petersburg Pediatric Medical Academy, Russia.

出版信息

J Hum Hypertens. 1996 Aug;10(8):557-9.

PMID:8895041
Abstract

We studied the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in 131 young males with borderline hypertension (BHT) and in 87 normotensive (NT) young males as a control group using polymerase chain reaction (PCR) technique. The allele frequencies of insertion and deletion ACE alleles were not different in both groups. These results suggest that I/D polymorphism of the ACE gene is not associated with a BHT in males of St Petersburg.

摘要

我们采用聚合酶链反应（PCR）技术，对131名患有临界高血压（BHT）的年轻男性以及作为对照组的87名血压正常（NT）的年轻男性，研究了血管紧张素转换酶（ACE）基因的插入/缺失（I/D）多态性。两组中插入和缺失ACE等位基因的频率并无差异。这些结果表明，ACE基因的I/D多态性与圣彼得堡男性的临界高血压无关。

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