比利时人群中血管紧张素转换酶基因I/D多态性与原发性高血压之间无关联。
Lack of association between the I/D polymorphism of the angiotensin-converting enzyme gene and essential hypertension in a Belgian population.
作者信息
Gu X X, Spaepen M, Guo C, Fagard R, Amery A, Lijnen P, Cassiman J J
机构信息
Centre for Human Genetics, University of Leuven, Belgium.
出版信息
J Hum Hypertens. 1994 Sep;8(9):683-5.
PMID:7807498
Abstract
We tested the insertion/deletion (I/D) polymorphism of the ACE gene in 119 hypertensive patients and in 109 normotensive controls by means of the polymerase chain reaction (PCR). The allele and genotype frequencies of the I/D polymorphism in the ACE gene are essentially identical in both groups, regardless of age or sex. The I/D polymorphism of the ACE gene is thus not implicated in Belgian hypertensive patients.
摘要
我们通过聚合酶链反应（PCR）检测了119例高血压患者和109例血压正常对照者血管紧张素转换酶（ACE）基因的插入/缺失（I/D）多态性。无论年龄或性别，两组中ACE基因I/D多态性的等位基因和基因型频率基本相同。因此，ACE基因的I/D多态性与比利时高血压患者无关。
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