Schnitz W, Taylor-Albert E, Targoff I N, Reichlin M, Scofield R H
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.
J Rheumatol. 1996 Oct;23(10):1729-33.
To characterize patients with anti-PM/Scl but no definite myositis-scleroderma (PM/SSc) overlap or either polymyositis/dermatomyositis (PM/DM) or systemic sclerosis (SSc) alone.
Review of all patients with anti-PM/Scl identified at a reference serologic clinical laboratory.
We identified 5 patients with anti-PM/Scl not considered to have either PM, SSc, or PM/SSc. One had primary Sjögren's syndrome but the other 4 had some feature(s) of illness consistent with PM/DM or SSc, such as hypertensive crisis or interstitial lung disease. These 5 patients represented 10% of the total number of patients with anti-PM/Scl identified in our clinical laboratory.
Anti-PM/Scl may be a marker for atypical or subclinical presentations of the usually associated disease, or this autoantibody may precede expression of the underlying disease. The antibody may also be present in patients who never express PM, SSc, or PM/SSc. Anti-PM/Scl without the usually described illnesses is not uncommon in our series of 55 patients with anti-PM/Scl.
对具有抗PM/Scl抗体但无明确的皮肌炎 - 硬皮病（PM/SSc）重叠综合征，或单独患有多发性肌炎/皮肌炎（PM/DM）或系统性硬化症（SSc）的患者进行特征描述。
回顾在一家参考血清学临床实验室确诊的所有抗PM/Scl抗体阳性患者。
我们鉴定出5例抗PM/Scl抗体阳性患者，他们不被认为患有PM、SSc或PM/SSc。1例患有原发性干燥综合征，其他4例有一些与PM/DM或SSc相符的疾病特征，如高血压危象或间质性肺病。这5例患者占我们临床实验室鉴定出的抗PM/Scl抗体阳性患者总数的10%。
抗PM/Scl抗体可能是通常相关疾病非典型或亚临床表型的标志物，或者这种自身抗体可能先于潜在疾病的表现出现。该抗体也可能存在于从未表现出PM、SSc或PM/SSc的患者中。在我们这组55例抗PM/Scl抗体阳性患者中，不伴有通常所描述疾病的抗PM/Scl抗体并不罕见。
