重新审视追踪稳态睡眠压力的大脑基因表达变化和蛋白质修饰。
Revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressure.
作者信息
Mongrain Valérie, Frank Marcos G, Leduc Tanya
机构信息
Department of Neuroscience, Université de Montréal, Montréal, QC Canada.
Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, QC Canada.
出版信息
NPJ Biol Timing Sleep. 2025;2(1):30. doi: 10.1038/s44323-025-00045-1. Epub 2025 Aug 4.
This review describes how transcriptomic/proteomic studies have contributed identifying molecular markers of sleep homeostasis and offers a perspective on the need to interrogate more comprehensively different dynamics, brain regions, and cell types. Modifications in molecular dynamics with development/aging are also emphasized. We suggest the concept of sleep homeostasis to be regarded as a variety of homeostats (not a single one) serving different functions for the brain across the lifespan.
本综述描述了转录组学/蛋白质组学研究如何有助于识别睡眠稳态的分子标志物，并就更全面地研究不同动态、脑区和细胞类型的必要性提出了一种观点。还强调了随着发育/衰老分子动态的变化。我们建议将睡眠稳态的概念视为多种稳态调节器（而非单一的一种），在整个生命周期中为大脑发挥不同功能。
Zotero 插件