Chung F L, Chen H J, Nath R G
Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, NY 10595, USA.
Carcinogenesis. 1996 Oct;17(10):2105-11. doi: 10.1093/carcin/17.10.2105.
A number of promutagenic exocyclic DNA adducts have recently been detected in both humans and rodents without carcinogen treatment. These observations raised questions about their origins and potential significance in carcinogenesis. In this commentary, we present our views pertaining to the in vivo sources of these cyclic adducts, specifically the cyclic propano and etheno adducts. The basis for our discussion comes mainly from the information generated through a span of more than a decade from several laboratories, including ours. This commentary summarizes the data from the chemical and biochemical studies that provide support for the hypothesis that lipid peroxidation is involved in the endogenous formation of these exocyclic adducts.
最近在未经致癌物处理的人类和啮齿动物中均检测到了多种前诱变外环DNA加合物。这些观察结果引发了关于它们的来源及其在致癌作用中的潜在意义的问题。在本评论中，我们阐述了关于这些环状加合物体内来源的观点，特别是环状丙烷和乙烯基加合物。我们讨论的依据主要来自包括我们实验室在内的多个实验室历经十多年所产生的信息。本评论总结了化学和生化研究的数据，这些数据为脂质过氧化参与这些外环加合物的内源性形成这一假说提供了支持。
