Männistö S, Pietinen P, Pyy M, Palmgren J, Eskelinen M, Uusitupa M
Department of Nutrition, National Public Health Institute, Helsinki, Finland.
Int J Cancer. 1996 Sep 27;68(1):8-13. doi: 10.1002/(SICI)1097-0215(19960927)68:1<8::AID-IJC2>3.0.CO;2-V.
Associations between the risk of breast cancer and body-size indicators at the time of breast-cancer diagnosis were assessed among 328 pre-menopausal or post-menopausal cases and 417 controls participating in the Kuopio Breast Cancer Study. This case-control study follows the protocol of the international Collaborative Study of Breast and Colorectal Cancer. When the potential confounding factors were taken into account, tallness was related to increased risk of breast cancer, especially in post-menopausal women, whereas no clear association with body-mass index (BMI) was found. Waist-to-hip ratio (WHR) was the most important risk factor in both pre-menopausal and post-menopausal women. The post-menopausal cases with high positive estrogen-receptor status (ER++) had the highest weight and BMI; they had also the biggest weight gain since the age of 20. However, the association between WHR and breast cancer appeared to be independent of estrogen-receptor status. Our results suggest that WHR may be a better marker for breast cancer than the degree of adiposity.
在参与库奥皮奥乳腺癌研究的328例绝经前或绝经后乳腺癌病例和417例对照中，评估了乳腺癌诊断时的风险与身体大小指标之间的关联。这项病例对照研究遵循国际乳腺癌和结直肠癌协作研究的方案。在考虑潜在的混杂因素后，身高与乳腺癌风险增加有关，尤其是在绝经后女性中，而未发现与体重指数（BMI）有明确关联。腰臀比（WHR）是绝经前和绝经后女性中最重要的风险因素。雌激素受体状态为高度阳性（ER++）的绝经后病例体重和BMI最高；自20岁以来体重增加也最大。然而，WHR与乳腺癌之间的关联似乎独立于雌激素受体状态。我们的结果表明，WHR可能是比肥胖程度更好的乳腺癌标志物。
