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犬离体前肢跨毛细血管的斯塔林力相互作用

Interaction of transcapillary Starling forces in the isolated dog forelimb.

作者信息

Brace R A, Guyton A C

出版信息

Am J Physiol. 1977 Jul;233(1):H136-40. doi: 10.1152/ajpheart.1977.233.1.H136.

DOI:10.1152/ajpheart.1977.233.1.H136
PMID:889604
Abstract

Three of the four Starling forces were measured in the intact dog forelimb after anesthetization and all four of the Starling forces were measured in the same forelimb which was surgically isolated yet innervated. In the isolated forelimb, isogravimetric capillary pressure (Pci) averaged 15.6 mmHg; colloid osmotic pressure of the plasma proteins (IIp) averaged 19.9 mmHg; mean interstitial fluid pressure (Pif) was +0.4 mmHg, and the average value of interstitial colloid osmotic pressure (IIif) was 4.9 mmHg. Thus the net imbalance in the Starling forces, i.e., (Pci - Pif) - (IIp - IIif), averaged 0.3 mmHg. Furthermore, the value of IIif was consistently decreased after isolation (average decrease of 1.2 mmHg) while Pif was always increased following isolation (average increase of 4.3 mmHg). In addition, it was found that if the forelimb was denervated during isolation, then Pif was increased by an average of 2 mmHg above Pif in the innervated, isolated forelimb. In summary, these studies show that the differences between the intact and isolated forelimb are that Pci averages 10-11 mmHg in the intact forelimb and 15-16 mmHg in the isolated innervated forelimb while interstitial fluid pressure is negative in the intact limb and positive in the isolated limb.

摘要

在麻醉后的完整犬前肢中测量了四种斯塔林力中的三种,并在同一手术分离但仍有神经支配的前肢中测量了所有四种斯塔林力。在分离的前肢中,等重力毛细血管压力(Pci)平均为15.6 mmHg;血浆蛋白的胶体渗透压(IIp)平均为19.9 mmHg;平均组织间液压力(Pif)为+0.4 mmHg,组织间胶体渗透压(IIif)的平均值为4.9 mmHg。因此,斯塔林力的净失衡,即(Pci - Pif)-(IIp - IIif),平均为0.3 mmHg。此外,分离后IIif的值持续下降(平均下降1.2 mmHg),而Pif在分离后总是升高(平均升高4.3 mmHg)。此外,还发现如果在前肢分离过程中使其去神经支配,那么Pif比有神经支配的分离前肢中的Pif平均升高2 mmHg。总之,这些研究表明,完整前肢和分离前肢之间的差异在于,完整前肢中Pci平均为10 - 11 mmHg,有神经支配的分离前肢中为15 - 16 mmHg,而组织间液压力在完整肢体中为负,在分离肢体中为正。

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