Carmack M A, Yasukawa L L, Chang S Y, Tran C, Saldana F, Arvin A M, Prober C G
Department of Pediatrics, Stanford University School of Medicine, California, USA.
J Infect Dis. 1996 Nov;174(5):899-906. doi: 10.1093/infdis/174.5.899.
T cell recognition of common and type-specific herpes simplex virus (HSV) glycoproteins was measured in 72 subjects. T cells were stimulated with whole HSV-2 antigen and glycoproteins gB2, gD2, and gG2. T cell proliferation in response to HSV-2 antigen and gG2 was significantly higher in subjects with HSV-2 infection than in those with HSV-1 infection only; responses to gB2 and gD2 were the same. T helper (Th) type 1 and Th2 cytokine production in response to whole HSV-2 antigen, gB2, and gD2 was evaluated in 33 subjects. Interleukin (IL)-2 and interferon-gamma responses to most antigens were significantly higher among HSV-2-seropositive subjects than among seronegative subjects. IL-4 synthesis was negligible; IL-10 was produced in seronegative and seropositive persons, but HSV-2 antigen responses were significantly higher in HSV-2-seropositive persons. Naturally acquired immunity to HSV involves T cell recognition of common and type-specific glycoproteins, prominent Th1 responses, and discordant Th2 responses with little IL-4 but substantial IL-10 production.
在72名受试者中检测了T细胞对常见和特定型单纯疱疹病毒（HSV）糖蛋白的识别。用完整的HSV - 2抗原以及糖蛋白gB2、gD2和gG2刺激T细胞。与仅感染HSV - 1的受试者相比，感染HSV - 2的受试者对HSV - 2抗原和gG2的T细胞增殖显著更高；对gB2和gD2的反应相同。在33名受试者中评估了T辅助（Th）1型和Th2型细胞因子对完整HSV - 2抗原、gB2和gD2的产生情况。HSV - 2血清阳性受试者中，白细胞介素（IL）- 2和干扰素 - γ对大多数抗原的反应显著高于血清阴性受试者。IL - 4的合成可忽略不计；IL - 10在血清阴性和血清阳性人群中均有产生，但HSV - 2血清阳性人群对HSV - 2抗原的反应显著更高。对HSV的自然获得性免疫涉及T细胞对常见和特定型糖蛋白的识别、显著的Th1反应以及不一致的Th2反应，IL - 4产生很少但IL - 10产生大量。
