Varis T, Vesikari T
Department of Virology, University of Tampere Medical School, Finland.
J Infect Dis. 1996 Nov;174 Suppl 3:S330-4. doi: 10.1093/infdis/174.supplement_3.s330.
The efficacy of a high-titer, reformulated varicella vaccine was studied in 513 10- to 30-month-old children. Vaccinees were randomly allocated to 5 groups to receive one of two lots of an original high-titer vaccine, one of two lots of a partially heat-inactivated vaccine, or placebo. Both vaccines were well tolerated. Seroconversion was detected in 100% and 99% of children immunized with the high- and low-titer vaccines, respectively. Sixty-five cases of serologically confirmed varicella-like disease were discovered during follow-up (mean, 29.3 months): 5 in the high-titer vaccine group, 19 in the low-titer vaccine group, and 41 in the placebo group (P < or = .005 for each difference). Thus, the protective efficacy of live attenuated varicella vaccine is dependent on vaccine titer. High-titer varicella vaccine induces excellent protection in healthy young children.
在513名10至30个月大的儿童中研究了一种高滴度、重新配制的水痘疫苗的疗效。将接种疫苗者随机分为5组，分别接种两批原始高滴度疫苗中的一批、两批部分热灭活疫苗中的一批或安慰剂。两种疫苗的耐受性均良好。分别在接种高滴度和低滴度疫苗的儿童中检测到100%和99%的血清转化。在随访期间（平均29.3个月）发现65例血清学确诊的水痘样疾病：高滴度疫苗组5例，低滴度疫苗组19例，安慰剂组41例（每组差异P≤0.005）。因此，减毒活水痘疫苗的保护效力取决于疫苗滴度。高滴度水痘疫苗能在健康幼儿中诱导出极佳的保护作用。
