Stewart W H
U.S. Statistics, Hoechst Marion Roussel, Inc., Kansas City, Missouri 64134-0627, USA.
Am J Hypertens. 1996 Oct;9(10 Pt 2):83S-86S; discussion 87S-90S. doi: 10.1016/0895-7061(96)00268-3.
The trough-to-peak ratio has recently come into prominence as a statistic to evaluate the clinical duration of effect for an antihypertensive medication. The statistic is unusual in that it is defined as the ratio of mean drug effect (compared to placebo) at trough compared to that at peak. There is no corresponding measure available on individual patients. This paper will examine the criteria needed to make the trough-to-peak ratio a useful, interpretable statistic. In addition, other possible trough-to-peak measures and statistics are considered for their potential usefulness in describing diurnal blood pressure (BP) data.
谷峰比值最近作为一种评估抗高血压药物临床疗效持续时间的统计指标而备受关注。该统计指标不同寻常之处在于，它被定义为谷值时（与安慰剂相比）的平均药物效应与峰值时的平均药物效应之比。目前尚无针对个体患者的相应测量方法。本文将探讨使谷峰比值成为一个有用且可解释的统计指标所需的标准。此外，还考虑了其他可能的谷峰测量方法和统计指标，以评估它们在描述昼夜血压（BP）数据方面的潜在用途。
