高胆固醇饮食对兔主动脉兴奋性的影响。

Effect of a cholesterol-rich diet on the excitability of rabbit aorta.

作者信息

Wong K K

机构信息

Department of Pharmacology, National Yang Ming University, Taipei, Taiwan, Republic of China.

出版信息

Biochem Mol Biol Int. 1996 Oct;40(2):389-93. doi: 10.1080/15216549600201882.

DOI:10.1080/15216549600201882

PMID:8896761

Abstract

The level of plasma total cholesterol in rabbits after 8-week feeding on a cholesterol-rich diet was raised significantly. The excitability of the rabbit aorta in response to the depolarizing agent KCl was enhanced, demonstrating an increased sensitivity to KCl stimulation as well as an increase of the KCl-induced maximum tension. It is speculated that 7 weeks of hypercholesterol state may vary the membrane lipid composition, enhancing the aortic excitability in response to depolarizing agent.

摘要

在以富含胆固醇的饮食喂养8周后，兔子血浆总胆固醇水平显著升高。兔子主动脉对去极化剂氯化钾的兴奋性增强，表明对氯化钾刺激的敏感性增加以及氯化钾诱导的最大张力增加。据推测，7周的高胆固醇状态可能会改变膜脂质组成，增强主动脉对去极化剂的兴奋性。