Rosenberg L J, Lucas J H
Department of Physiology, Ohio State University, Columbus 43210, USA.
Brain Res. 1996 Sep 23;734(1-2):349-53.
Neurites were transected from spinal neurons in media with normal (125 microM) or reduced NaCl (sucrose substitution). After 12 h the normal ionic environment (conditioned medium with serum) was restored. A one-factor ANOVA comparison found a significant difference in 48 h survival (P = 0.0001). Survival was highest when NaCl was reduced 50% (74% +/- 19 vs. 22% +/- 19 in normal NaCl). Na(+)- and Cl-mediated deterioration may contribute to both gray and white matter injury in CNS trauma.
在含有正常（125微摩尔）或降低的氯化钠（用蔗糖替代）的培养基中，从脊髓神经元切断神经突。12小时后恢复正常离子环境（含血清的条件培养基）。单因素方差分析比较发现在48小时存活率上存在显著差异（P = 0.0001）。当氯化钠降低50%时存活率最高（74%±19 vs.正常氯化钠条件下的22%±19）。钠和氯介导的退化可能导致中枢神经系统创伤中灰质和白质的损伤。
