降低氯化钠浓度可提高遭受树突横断损伤的哺乳动物脊髓神经元的存活率。
Reduction of NaCl increases survival of mammalian spinal neurons subjected to dendrite transection injury.
作者信息
Rosenberg L J, Lucas J H
机构信息
Department of Physiology, Ohio State University, Columbus 43210, USA.
出版信息
Brain Res. 1996 Sep 23;734(1-2):349-53.
Neurites were transected from spinal neurons in media with normal (125 microM) or reduced NaCl (sucrose substitution). After 12 h the normal ionic environment (conditioned medium with serum) was restored. A one-factor ANOVA comparison found a significant difference in 48 h survival (P = 0.0001). Survival was highest when NaCl was reduced 50% (74% +/- 19 vs. 22% +/- 19 in normal NaCl). Na(+)- and Cl-mediated deterioration may contribute to both gray and white matter injury in CNS trauma.
在含有正常（125微摩尔）或降低的氯化钠（用蔗糖替代）的培养基中，从脊髓神经元切断神经突。12小时后恢复正常离子环境（含血清的条件培养基）。单因素方差分析比较发现在48小时存活率上存在显著差异（P = 0.0001）。当氯化钠降低50%时存活率最高（74%±19 vs.正常氯化钠条件下的22%±19）。钠和氯介导的退化可能导致中枢神经系统创伤中灰质和白质的损伤。
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