Marin M L, Veith F J, Cynamon J, Parsons R E, Lyon R T, Suggs W D, Bakal C W, Waahl S, Sanchez L A, Yuan J G, Ohki T
Department of Surgery, Montefiore Medical Center, University Hospital, Albert Einstein College of Medicine, New York, NY 10467, USA.
J Vasc Interv Radiol. 1996 Sep-Oct;7(5):651-6. doi: 10.1016/s1051-0443(96)70823-0.
The occurrence of neointimal hyperplasia within a stent may result in restenosis with recurrent symptoms of end-organ ischemia. This study evaluated the potential of a nonporous covering of a stent to function as a barrier to the formation of intrastent neointimal hyperplasia.
Twelve endovascular stent grafts were used to treat 12 high-risk patients with limb-threatening ischemia secondary to long-segment iliac artery occlusion. A 6-mm, thin-walled polytetrafluoroethylene graft was inserted and anchored to the common iliac artery with use of Palmaz stents. Each stent was covered by graft material over one-half of its length. Control angiograms obtained immediately after graft insertion were compared with follow-up angiograms obtained between 4 and 6 months after the initial procedure. On each angiogram, the region of the stent was magnified by 20x to permit computerized luminal diameter measurements.
The mean luminal diameter within the stent was significantly greater on the covered (7.7 mm +/- 0.33 standard deviation) compared with the uncovered (6.7 mm +/- 0.85 standard deviation) portions (P < .01).
Partially covered stents are a unique model for assessing the effects of an extrinsic stent covering on arterial healing and myointimal hyperplasia. These data suggest that a relatively nonporous covering of polytetrafluoroethylene may inhibit stent-related restenosis in iliac arteries.
支架内新生内膜增生的发生可能导致再狭窄，并伴有终末器官缺血的复发症状。本研究评估了无孔支架覆盖物作为支架内新生内膜增生形成屏障的潜力。
使用12个血管内支架移植物治疗12例因长段髂动脉闭塞导致肢体威胁性缺血的高危患者。插入一个6毫米的薄壁聚四氟乙烯移植物，并用帕尔马兹支架将其锚定在髂总动脉上。每个支架在其长度的一半以上被移植物材料覆盖。将移植物插入后立即获得的对照血管造影与初始手术后4至6个月获得的随访血管造影进行比较。在每张血管造影上，将支架区域放大20倍以进行计算机化管腔直径测量。
与未覆盖部分（6.7毫米±0.85标准差）相比，覆盖部分（7.7毫米±0.33标准差）内支架的平均管腔直径显著更大（P <.01）。
部分覆盖的支架是评估外部支架覆盖对动脉愈合和肌内膜增生影响的独特模型。这些数据表明，聚四氟乙烯相对无孔的覆盖物可能抑制髂动脉中与支架相关的再狭窄。
