Durstine J L, Ferguson M A, Szymanski L M, Davis P G, Alderson N L, Trost S G, Pate R R
Department of Exercise Science, University of South Carolina, Columbia 29208, USA.
Med Sci Sports Exerc. 1996 Oct;28(10):1277-81. doi: 10.1097/00005768-199610000-00011.
Lipoprotein(a) (Lp(a)) is bound to apolipoprotein B-100 by disulfide linkage and is associated in the upper density range of low density lipoprotein cholesterol. Persons with elevated concentrations of Lp(a) are regarded as having an increased risk for premature coronary artery disease. Although many studies exist evaluating the effects of a single session of exercise on lipids and lipoproteins, little information is available concerning the effects of exercise on Lp(a). Therefore, the purpose of this study was to determine the effects of a single exercise session on plasma Lp(a). Twelve physically active men completed two 30-min submaximal treadmill exercise sessions: low intensity (LI, 50% VO2max) and high intensity (HI, 80% VO2max). Blood samples were obtained immediately before and after exercise. Total cholesterol (LI: before 4.22 +/- 0.26, after 4.24 +/- 0.28; HI: before 4.24 +/- 0.31, after 4.11 +/- 0.28 mmol.l-1, mean +/- SE) and triglyceride (LI: before 1.14 +/- 0.16, after 1.06 +/- 0.16; HI: before 1.12 +/- 0.19, after 1.21 +/- 0.19 mmol.l-1) concentrations did not differ immediately after either exercise session, nor did Lp(a) concentrations differ immediately after either exercise session (LI: before 4.1 +/- 2.2, after 4.0 +/- 2.1: HI: before 3.9 +/- 2.2, after 3.7 +/- 2.0 mg.dl-1). These results suggest that neither a low nor a high intensity exercise session lasting 30 min in duration has an immediate effect on plasma Lp(a).
脂蛋白(a) [Lp(a)] 通过二硫键与载脂蛋白B-100结合，并与低密度脂蛋白胆固醇的较高密度范围相关。Lp(a)浓度升高的人被认为患早发性冠状动脉疾病的风险增加。尽管有许多研究评估单次运动对脂质和脂蛋白的影响，但关于运动对Lp(a)的影响的信息却很少。因此，本研究的目的是确定单次运动对血浆Lp(a)的影响。12名身体活跃的男性完成了两次30分钟的次最大强度跑步机运动：低强度（LI，50%最大摄氧量）和高强度（HI，80%最大摄氧量）。在运动前后立即采集血样。总胆固醇（LI：运动前4.22±0.26，运动后4.24±0.28；HI：运动前4.24±0.31，运动后4.11±0.28 mmol·l-1，均值±标准误）和甘油三酯（LI：运动前1.14±0.16，运动后1.06±0.16；HI：运动前1.12±0.19，运动后1.21±0.19 mmol·l-1）浓度在任何一次运动后均无差异，Lp(a)浓度在任何一次运动后也无差异（LI：运动前4.1±2.2，运动后4.0±2.1；HI：运动前3.9±2.2，运动后3.7±2.0 mg·dl-1）。这些结果表明，持续30分钟的低强度或高强度运动对血浆Lp(a)均无即时影响。
