Spiegel J, Hansen C, Treede R D
Institute of Physiology and Pathophysiology, Johannes Gutenberg-University Mainz, Germany.
Neurosci Lett. 1996 Oct 4;216(3):179-82. doi: 10.1016/0304-3940(96)13025-1.
The vertex potential (N2, P2) of the laser-evoked potential (LEP) is preceded by a small negativity (N1). The role of the secondary somatosensory cortex (SII) in generation of the N1 is established for the upper but not for the lower limb. We therefore investigated the N1 after painful radiant heat stimulation of hand and foot dorsum in 22 subjects. LEPs were recorded from the scalp with midline and temporal electrodes. After hand stimulation N1 was maximal in the contralateral temporal lead (mean peak latency 156 +/- 23 ms). After foot stimulation N1 was maximal in the same lead (200 +/- 22 ms). In the ipsilateral temporal lead, N1 appeared significantly smaller and later. N2 and P2 were maximal in midline electrodes for both stimulus sites. The latency shift between hand and foot stimulation was identical for all three components. These results suggest a contribution of temporo-parietal cortex (e.g. SII) to the N1 generation for stimulation of upper and lower limb.
激光诱发电位（LEP）的顶点电位（N2、P2）之前有一个小的负波（N1）。二级体感皮层（SII）在N1产生中对上肢的作用已得到证实，但对下肢尚未明确。因此，我们对22名受试者的手背和足背进行疼痛性热辐射刺激后，研究了N1。用中线和颞部电极从头皮记录LEP。手部刺激后，N1在对侧颞部导联最大（平均峰潜伏期156±23毫秒）。足部刺激后，N1在同一导联最大（200±22毫秒）。在同侧颞部导联，N1明显较小且出现较晚。两个刺激部位的N2和P2在中线电极处最大。手部和足部刺激之间的潜伏期偏移在所有三个成分中相同。这些结果表明，颞顶叶皮层（如SII）对上肢和下肢刺激的N1产生有贡献。
