MacKenzie I Z, Pooley G, Challis J R
Br J Obstet Gynaecol. 1977 Aug;84(8):608-12. doi: 10.1111/j.1471-0528.1977.tb12663.x.
The effects of intra-amniotic prostaglandin E2 (PGE2) and PGF2alpha on the concentration of cortisol in amniotic fluid and in maternal peripheral plasma of patients undergoing abortion between 16 and 23 weeks gestation have been examined. There was a significant (P less than 0-01) increase in the concentration of cortisol in amniotic fluid for hours after PGE2, but not after PGF2alpha. The concentration of cortisol in the maternal peripheral plasma increased in both groups with the progression of abortion, but the levels were not significantly correlated with those in amniotic fluid. These results suggest that by mid-pregnancy fetal cortisol production can be stimulated by PGE2 but the mechanism of this action remains to be elucidated.
研究了羊膜腔内注射前列腺素E2（PGE2）和前列腺素F2α（PGF2α）对妊娠16至23周行人工流产患者羊水及母体外周血浆中皮质醇浓度的影响。注射PGE2后数小时，羊水中皮质醇浓度显著升高（P<0.01），而注射PGF2α后未出现这种情况。随着流产过程的进展，两组母体外周血浆中皮质醇浓度均升高，但这些水平与羊水中的皮质醇浓度无显著相关性。这些结果表明，在妊娠中期，PGE2可刺激胎儿皮质醇的产生，但其作用机制仍有待阐明。
