Buítkamp J, Filmether P, Stear M J, Epplen J T
Department of Animal Breeding, Technical University Munich, Germany.
Parasitol Res. 1996;82(8):693-6. doi: 10.1007/s004360050187.
During a previous investigation an association was found between major histocompatibility complex (MHC)-DRB1 alleles and faecal egg counts following natural infection predominantly involving Ostertagia circumcincta in a flock of Scottish Blackface sheep. To localise the disease-resistance locus we screened the same flock for an MHC class I microsatellite and a newly developed microsatellite for the DY locus located in the class IIb subregion. Some alleles at both additional loci were associated with resistance to infection. Least-squares analysis of variance indicated that in 6-month-old lambs, substitution of the most common alleles by the alleles associated with resistance would result in an 8- and a 218-fold reduction in faecal egg counts for MHC class I and DY, respectively. These results indicate that genes within the MHC genes play a large and significant role in the development of resistance to a widespread, important and natural parasite.
在之前的一项调查中，发现主要组织相容性复合体（MHC）-DRB1等位基因与一群苏格兰黑脸羊自然感染（主要感染环形泰勒虫）后的粪便虫卵计数之间存在关联。为了定位抗病基因座，我们在同一羊群中筛选了一个MHC I类微卫星和一个新开发的位于IIb亚区域的DY基因座微卫星。这两个额外基因座的一些等位基因与感染抗性相关。最小二乘方差分析表明，在6月龄羔羊中，用与抗性相关的等位基因替代最常见的等位基因，MHC I类和DY的粪便虫卵计数将分别降低8倍和218倍。这些结果表明，MHC基因中的基因在对一种广泛、重要的自然寄生虫的抗性发展中起着重大且显著的作用。
