α-亚麻酸（18:3ω3）对大鼠γ-亚麻酸（18:3ω6）代谢的影响。
The influence of alpha-linolenic acid (18: 3omega3) on the metabolism of gamma-linolenic acid (18: 3omega6) in the rat.
作者信息
Hassam A G
出版信息
Br J Nutr. 1977 Jul;38(1):137-40. doi: 10.1079/bjn19770069.
PMID:889767
Abstract
- Essential fatty acid-deficient rats were fed gamma-linolenic acid (18: 3omega6) at 2% dietary energy and alpha-linolenic acid (18: 3omega3) at 0, 1-6, 2-8 and 4-0% of the dietary energy. 2. 18: 3omega3 at 1-6% apparently inhibits the synthesis of the C20 and C22 omega6 long-chain polyunsaturated fatty acids (omega6 LC-PUFA) metabolized from 18: 3omega6. 3. However, increasing the dietary levels of 18: 3omega3 from 1-6 to 4-0% has no further influence. 4. The results suggest that dietary 18: 3omega6 is an efficent precursor for the omega6 LC-PUFA synthesis even in the presence of 18: 3omega3.
摘要
- 给必需脂肪酸缺乏的大鼠喂食占膳食能量2%的γ-亚麻酸（18:3ω6）以及占膳食能量0%、1 - 6%、2 - 8%和4 - 0%的α-亚麻酸（18:3ω3）。2. 1 - 6%的18:3ω3明显抑制了由18:3ω6代谢而来的C20和C22ω6长链多不饱和脂肪酸（ω6 LC - PUFA）的合成。3. 然而，将18:3ω3的膳食水平从1 - 6%提高到4 - 0%没有进一步影响。4. 结果表明，即使存在18:3ω3，膳食中的18:3ω6仍是ω6 LC - PUFA合成的有效前体。
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