Steindl P E, Coy D L, Finn B, Zee P C, Blei A T
Department of Medicine, Lakeside Veterans Affairs Medical Center, Chicago, Illinois, USA.
Am J Physiol. 1996 Oct;271(4 Pt 1):G555-60. doi: 10.1152/ajpgi.1996.271.4.G555.
In previous studies we noted a disruption of the circadian locomotor activity rhythm in rats after portacaval anastomosis (PCA). To examine whether this abnormality is related to factors that aggravate hepatic encephalopathy in humans, we studied the effect of dietary formulation and protein content on body weight, locomotor activity, and entrainment to the light-dark cycle in rats after PCA or sham operation. Postoperative weight loss was prevented by pair-feeding with a purified liquid diet. However, the behavioral abnormalities persisted in PCA rats fed a high-protein diet, with a reduction in total activity and entrainment to the light-dark cycle. These were ameliorated by a low dietary protein content. Since this treatment reduces the load of gut-derived nitrogenous substances that might alter brain metabolism, our data strengthen the hypothesis that the abnormal circadian activity patterns in PCA rats may be part of the spectrum of hepatic encephalopathy.
在先前的研究中，我们注意到大鼠门腔静脉吻合术（PCA）后昼夜运动活动节律受到破坏。为了研究这种异常是否与加重人类肝性脑病的因素有关，我们研究了饮食配方和蛋白质含量对PCA或假手术后大鼠体重、运动活动以及对明暗周期的同步化的影响。通过用纯化的液体饮食进行配对喂养来防止术后体重减轻。然而，喂食高蛋白饮食的PCA大鼠的行为异常仍然存在，总活动量减少且对明暗周期的同步化受到影响。低饮食蛋白质含量可改善这些异常。由于这种处理减少了可能改变脑代谢的肠道来源含氮物质的负荷，我们的数据强化了这样一种假说，即PCA大鼠异常的昼夜活动模式可能是肝性脑病谱的一部分。
