Hamdy S, Aziz Q, Rothwell J C, Singh K D, Barlow J, Hughes D G, Tallis R C, Thompson D G
Department of Gastroenterology, Hope Hospital, University of Manchester, UK.
Nat Med. 1996 Nov;2(11):1217-24. doi: 10.1038/nm1196-1217.
Because no detailed information exists regarding the topographic representation of swallowing musculature on the human cerebral cortex in health or disease, we used transcranial magnetic stimulation to study the cortical topography of human oral, pharyngeal and esophageal musculature in 20 healthy individuals and the topography of pharyngeal musculature in two stroke patients, one with and one without dysphagia. Our results demonstrate that swallowing musculature is discretely and somatotopically represented on the motor and premotor cortex of both hemispheres but displays interhemispheric asymmetry, independent of handedness. Following stroke, dysphagia appeared to be associated with smaller pharyngeal representation on the intact hemisphere, which increases in size with recovery of swallowing.
由于目前尚无关于健康或患病状态下人类大脑皮质吞咽肌肉组织的地形学表征的详细信息，我们利用经颅磁刺激技术，研究了20名健康个体口腔、咽部和食管肌肉组织的皮质地形学，以及两名中风患者（一名有吞咽困难，一名没有吞咽困难）咽部肌肉组织的地形学。我们的研究结果表明，吞咽肌肉组织在两侧半球的运动皮质和运动前区皮质上呈离散性和躯体定位性表征，但显示出半球间的不对称性，且与利手无关。中风后，吞咽困难似乎与未受损半球上较小的咽部表征有关，随着吞咽功能的恢复，该表征区域会增大。
