Alvaro T, Bosch R, Salvadó M T, Piris M A
Department of Pathology, Verge de la Cinta Hospital, Tarragona, Spain.
Am J Surg Pathol. 1996 Nov;20(11):1406-11. doi: 10.1097/00000478-199611000-00013.
True histiocytic lymphoma is considered a rare entity, and its diagnosis requires the concordance of morphological, immunophenotypic, and molecular findings. The association of malignant lymphoma with tumors in the monocyte-macrophage system has rarely been described. We present a case of mucosa-associated lymphoid tissue (MALT)-type low-grade B-cell lymphoma of the stomach, contiguous to a large tumoral mass that fulfills the morphological criteria (large cells with abundant pale cytoplasm and lobulated or kidney-shaped nuclei) and immunophenotypical features (human leukocyte antigen-DR locus, CD68, S-100, lysozyme immunoreactivity, and negative B- and T-cell markers) required for the diagnosis of histiocytic lymphoma. The patient remains in complete remission 18 months after surgery. The association of low grade-malignant lymphoma with tumors of monocyte-macrophage system cells is an exceedingly rare phenomenon. Whether these tumors are directly related or occur due to pure chance requires the identification of new cases and further study.
真性组织细胞淋巴瘤被认为是一种罕见的疾病，其诊断需要形态学、免疫表型和分子学检查结果相互一致。恶性淋巴瘤与单核细胞 - 巨噬细胞系统肿瘤的关联鲜有报道。我们报告一例胃黏膜相关淋巴组织（MALT）型低度B细胞淋巴瘤，毗邻一个大的肿瘤块，该肿瘤块符合组织细胞淋巴瘤诊断所需的形态学标准（具有丰富淡染细胞质和分叶状或肾形核的大细胞）和免疫表型特征（人类白细胞抗原 - DR位点、CD68、S - 100、溶菌酶免疫反应性以及B细胞和T细胞标志物阴性）。该患者术后18个月仍处于完全缓解状态。低度恶性淋巴瘤与单核细胞 - 巨噬细胞系统细胞肿瘤的关联是一种极其罕见的现象。这些肿瘤是直接相关还是纯属偶然发生，需要发现新病例并进一步研究。
