Tong Jiankun, Luo Jean, Saldinger Pierre F, Rodgers William H
Department of Pathology, New York Presbyterian Queens, 56-45 Main Street, Flushing, NY 11355, USA.
Department of Surgery, New York Presbyterian Queens, 56-45 Main Street, Flushing, NY 11355, USA.
Case Rep Hematol. 2021 Mar 8;2021:8856649. doi: 10.1155/2021/8856649. eCollection 2021.
Histiocytic sarcoma is a rare malignant histiocytic neoplasm composed of cells with morphologic and immunophenotypic features of mature tissue histiocytes. It occurs anywhere in the body and behaves aggressively. However, its etiology is unknown. Here, we report a 68-year-old female who developed histiocytic sarcoma following chemotherapy with imatinib (Gleevec) for gastrointestinal stromal tumor. Possible mechanisms of transdifferentiation from gastrointestinal stromal tumor to histiocytic sarcoma are discussed based on the features of our case and other two similar cases in the literature.
组织细胞肉瘤是一种罕见的恶性组织细胞肿瘤，由具有成熟组织细胞形态学和免疫表型特征的细胞组成。它可发生于身体的任何部位，且侵袭性生长。然而，其病因尚不清楚。在此，我们报告一名68岁女性，她在接受伊马替尼（格列卫）治疗胃肠道间质瘤后发生了组织细胞肉瘤。基于我们病例的特征以及文献中另外两例相似病例，讨论了胃肠道间质瘤向组织细胞肉瘤转分化的可能机制。
