Caron J P, Kaneene J B, Miller R
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA.
J Am Vet Med Assoc. 1996 Nov 1;209(9):1564-8.
To determine the patterns of use and perceived efficacy of polysulfated glycosaminoglycan (PSGAG) for the treatment of degenerative joint disease in horses.
Cross-sectional mail survey.
1,522 equine practitioners.
Information was obtained on frequency and route of administration of PSGAG for the treatment of each of 4 forms of degenerative joint disease, the efficacy of PSGAG, and its efficacy compared with that of sodium hyaluronate. Data were analyzed by nonparametric and multivariate regression methods.
Response rate was 40.5%. Of practitioners responding, 26% were classified as having a special interest in lameness and 74% as general practitioners. Use of PSGAG was reported by 90.5% of all practitioners, but lameness practitioners used PSGAG more frequently than general practitioners. Use of PSGAG also was significantly more common among practitioners involved predominately with racing. Thoroughbreds, Standardbreds, or show horses. Use of PSGAG was reported to be moderately effective in the treatment of the 4 joint disease conditions. Practitioners treating Thoroughbred racehorses gave highest efficacy scores, and pleasure horse practitioners gave lowest efficacy scores. Use of PSGAG was considered more effective than sodium hyaluronate for the treatment of subacute degenerative joint disease and less effective for idiopathic joint effusion and acute synovitis.
Use of PSGAG is regarded as moderately effective overall and is considered most useful in the treatment of subacute degenerative joint disease. The efficacy of PSGAG for incipient and chronic forms of degenerative disease is considered comparable to that of sodium hyaluronate.
确定聚硫酸化糖胺聚糖（PSGAG）用于治疗马退行性关节疾病的使用模式和感知疗效。
横断面邮寄调查。
1522名马医从业者。
获取了关于PSGAG治疗4种退行性关节疾病中每种疾病的给药频率和途径、PSGAG的疗效及其与透明质酸钠疗效比较的数据。采用非参数和多变量回归方法进行数据分析。
回复率为40.5%。在回复的从业者中，26%被归类为对跛行有特殊兴趣，74%为普通从业者。所有从业者中有90.5%报告使用过PSGAG，但跛行方面的从业者比普通从业者更频繁地使用PSGAG。在主要涉及赛马、纯种马、标准赛马或表演马的从业者中，PSGAG的使用也明显更为普遍。据报告，PSGAG在治疗4种关节疾病方面有中等疗效。治疗纯种赛马的从业者给出的疗效评分最高，而休闲马从业者给出的疗效评分最低。对于亚急性退行性关节疾病的治疗，PSGAG被认为比透明质酸钠更有效，而对于特发性关节积液和急性滑膜炎则效果较差。
总体而言，PSGAG的使用被认为有中等疗效，并且被认为在治疗亚急性退行性关节疾病方面最有用。PSGAG对早期和慢性退行性疾病的疗效被认为与透明质酸钠相当。
