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[急性低温深度与犬和白鼠心肌线粒体脂质的组成及相变之间的关系]

[Relationship between the depth of acute hypothermia and the composition and phase transitions of mitochondrial lipids of dog and white rat myocardium].

作者信息

Shepelev A P

出版信息

Biofizika. 1977 May-Jun;22(3):465-7.

PMID:889906
Abstract

It has been found in the experiments on white rats and dogs that the increase of body temperature by 8--10 degrees in myocardium mitochondria composition of phospholipids is changed, microviscosity of lipids decreases, the phase transition is shifted to the low temperature region. Changes in white rats' mitochondria are expressed to a greater extent. When the body temperature is decreased by 18--20 degrees microviscosity of lipids in dog myocardium mitochondria increases, that of white rats is maintained on the same level. Effect of the composition of membrane lipids on the temerature of phase transitions during hypothermia is discussed, as well as possible dependence of the stability of animals towards low temperatures on the degree of reconstruction of the membrane lipids.

摘要

在对白鼠和狗的实验中发现,当体温升高8 - 10度时,心肌线粒体中磷脂的组成发生变化,脂质的微粘度降低,相变向低温区域转移。白鼠线粒体的变化表现得更为明显。当体温降低18 - 20度时,狗心肌线粒体中脂质的微粘度增加,白鼠的则保持在同一水平。讨论了低温期间膜脂组成对相变温度的影响,以及动物对低温的稳定性可能与膜脂重构程度的依赖关系。

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