Salzman D, Adkins D R, Craig F, Freytes C, LeMaistre C F
University of Alabama at Birmingham 35294-0006, USA.
Bone Marrow Transplant. 1996 Oct;18(4):755-60.
Pulmonary veno-occlusive disease (VOD) is a rare cause of pulmonary hypertension (HTN) which has been described in association with a variety of clinical conditions. Rapidly progressive occlusion of pulmonary veins and venules develops that is usually fatal. Recently, a number of cases have been reported in patients with malignancies. To date, 33 patients have developed pulmonary VOD in association with a malignancy or after chemotherapy and/or radiation therapy. Two-thirds of the cases occurred following allogeneic bone marrow transplantation (BMT). We describe the first case of pulmonary VOD following autologous BMT and review the experience of pulmonary VOD in patients with malignancies.
肺静脉闭塞病（VOD）是肺动脉高压（HTN）的一种罕见病因，已被描述与多种临床情况相关。肺静脉和小静脉迅速进展性闭塞，通常是致命的。最近，在恶性肿瘤患者中报告了多例病例。迄今为止，已有33例患者发生与恶性肿瘤相关或化疗和/或放疗后的肺VOD。三分之二的病例发生在异基因骨髓移植（BMT）后。我们描述了首例自体BMT后发生的肺VOD病例，并回顾了恶性肿瘤患者肺VOD的经验。
