Nowicky J W, Hiesmayr W, Nowicky W, Liepins A
Ukrainian Anti-Cancer Institute, Vienna, Austria.
Drugs Exp Clin Res. 1996;22(3-5):93-7.
Tumour cells were taken from human tumour xenografts (HTX) and serially transplanted into nude mice. These cells were used in a colony-forming assay in vitro. Tumour cells were incubated continuously for at least one week with several concentrations of the drug Ukrain. This was done with six different types and the colony formation was scored for each tumour. The drug effects were reported as percent T/C (Test/Control) for the numbers of colonies formed. Activity is considered to be present at T/C < 30%. A clear dose-response effect was found for Ukrain.
肿瘤细胞取自人肿瘤异种移植（HTX），并连续移植到裸鼠体内。这些细胞用于体外集落形成试验。将肿瘤细胞与几种浓度的药物 Ukrain 连续孵育至少一周。对六种不同类型的肿瘤细胞进行了上述操作，并对每种肿瘤的集落形成进行评分。药物效果以形成的集落数的 T/C（试验/对照）百分比表示。当 T/C < 30%时认为有活性。发现 Ukrain 具有明显的剂量反应效应。
