乌头碱连续十日给药对小鼠的镇痛作用及其与吗啡治疗的相互作用。
Antinociceptive effect of ten day administration of Ukrain in mice and interaction of the treatment with morphine.
作者信息
Jagiełło-Wojtowicz E, Kleinrok Z, Chodkowska A, Nowicky J W, Piper H, Kubiatowski T
机构信息
Department of Pharmacology, Medical Academy, Lublin, Poland.
出版信息
Drugs Exp Clin Res. 1996;22(3-5):201-3.
The present study shows that Ukrain, administered i.c. in doses of 9.5 and 19 mg/kg once daily for 10 days in mice, produced evident antinociceptive action in the writhing syndrome and hot-plate tests. Moreover, we found that as a result of 10-day treatment with Ukrain the antinociceptive action of morphine (0.1 mg/kg s.c. administered after the last dose of Ukrain) was significantly decreased. These results and the observed interaction between Ukrain and morphine seem to be contra-indications to their combined usage.
本研究表明，在小鼠中，以9.5和19毫克/千克的剂量每日一次腹腔注射 Ukrain，连续10天，在扭体综合征和热板试验中产生了明显的抗伤害感受作用。此外，我们发现，由于用 Ukrain 进行了10天的治疗，吗啡（在最后一剂 Ukrain 后皮下注射0.1毫克/千克）的抗伤害感受作用显著降低。这些结果以及观察到的 Ukrain 与吗啡之间的相互作用似乎是它们联合使用的禁忌。
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