Antinociceptive effect of ten day administration of Ukrain in mice and interaction of the treatment with morphine.

The present study shows that Ukrain, administered i.c. in doses of 9.5 and 19 mg/kg once daily for 10 days in mice, produced evident antinociceptive action in the writhing syndrome and hot-plate tests. Moreover, we found that as a result of 10-day treatment with Ukrain the antinociceptive action of morphine (0.1 mg/kg s.c. administered after the last dose of Ukrain) was significantly decreased. These results and the observed interaction between Ukrain and morphine seem to be contra-indications to their combined usage.