Shol'ts K F, Zakharova T S
Biokhimiia. 1977 May;42(5):809-14.
Comparative study of the effect normal saturated carboxulic acids of different carbon chain length (7-16 carbon atoms) on rat liver mitochondria respiration at 3 and 4 states (according to Chance) has revealed that these compounds are protonophores. The data on the dependence of the effect on the concentration of fatty acids suggest that the protein transfer through the mitochondrial membrane is carried out by a monomeric form, and the inhibitory effect is due to a dimeric form of these compounds. Inhibitory and activating properties of fatty acids are described by a theoretically deducted equation, which demonstrates similar activity for highest homologues, in spite of differences in their distribution coefficients between aqueous and lipid phases. It is also concluded that the same effect is due to the same molar concentration of fatty acid in the mitochondrial membrane.
对不同碳链长度（7 - 16个碳原子）的正饱和羧酸对大鼠肝脏线粒体在3态和4态（根据钱斯的定义）呼吸作用影响的比较研究表明，这些化合物是质子载体。关于该效应依赖于脂肪酸浓度的数据表明，蛋白质通过线粒体膜的转运是由单体形式进行的，而抑制效应则归因于这些化合物的二聚体形式。脂肪酸的抑制和激活特性由一个理论推导方程描述，该方程表明尽管它们在水相和脂相之间的分配系数存在差异，但最高同系物具有相似的活性。研究还得出结论，相同的效应是由于线粒体膜中相同摩尔浓度的脂肪酸所致。
