Ishankhodzhaev T M, Bornikov V T, Zaĭnutdinov B R, Saatov T S
Biokhimiia. 1987 Feb;52(2):220-4.
The lipid composition and fatty acid spectrum of individual phospholipid fractions of internal and external membranes of mitochondria was studied in alloxan diabetes. It was found that the phosphatidylserine content is reduced under these conditions, while those of lysophosphatidylcholines, diphosphatidylglycerols and cholesterol are increased, and the fatty acids are saturated with phospholipids. The observed changes in the lipid composition of membranes cause a decrease in the rate of oxygen consumption in various metabolic states as well as in the activity of NAD X H+-, succinate and cytochrome oxidases in rat liver mitochondria.
研究了四氧嘧啶糖尿病大鼠线粒体内膜和外膜各磷脂组分的脂质组成及脂肪酸谱。发现在这些条件下，磷脂酰丝氨酸含量降低，而溶血磷脂酰胆碱、二磷脂酰甘油和胆固醇含量增加，并且脂肪酸在磷脂中呈饱和状态。观察到的膜脂质组成变化导致大鼠肝线粒体在各种代谢状态下的耗氧率降低，以及NAD X H + -、琥珀酸和细胞色素氧化酶的活性降低。
