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仓鼠边缘核中的神经肽Y:与P物质无共定位

Neuropeptide Y in hamster limbic nuclei: lack of colocalization with substance P.

作者信息

Burroughs L F, Fiber J M, Swann J M

机构信息

Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA.

出版信息

Peptides. 1996;17(6):1053-62. doi: 10.1016/0196-9781(96)00130-1.

DOI:10.1016/0196-9781(96)00130-1
PMID:8899827
Abstract

The medial nucleus of the amygdala (Me), bed nucleus of the stria terminalis (BNST), and medial preoptic area (MPOA) regulate copulation in the male hamster. The present study identified neuropeptide Y-immunoreactive (NPY-IR) neurons in the BNST and Me with the greatest concentration in the posteromedial and posteriordorsal subdivisions of these nuclei, respectively. NPY-IR filters are found in all three nuclei with dense plexi of NPY-IR varicosities in the most medial subdivisions. Substance P neurons are also densely concentrated in the posterior BNST and Me; however, no neurons contained both peptides. Thus, NPY and substance P neurons comprise two distinct populations within the BNST and Me of the hamster.

摘要

杏仁核内侧核(Me)、终纹床核(BNST)和内侧视前区(MPOA)调节雄性仓鼠的交配行为。本研究在BNST和Me中鉴定出神经肽Y免疫反应性(NPY-IR)神经元,这些神经元分别在这些核的后内侧和后背部亚区中浓度最高。在所有这三个核中均发现了NPY-IR纤维,在最内侧亚区有密集的NPY-IR曲张体丛。P物质神经元也密集地集中在BNST后部和Me中;然而,没有神经元同时包含这两种肽。因此,NPY和P物质神经元在仓鼠的BNST和Me中构成两个不同的群体。

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