大型梭菌细胞毒素——一类修饰小GTP结合蛋白的糖基转移酶家族。

Large clostridial cytotoxins--a family of glycosyltransferases modifying small GTP-binding proteins.

作者信息

von Eichel-Streiber C, Boquet P, Sauerborn M, Thelestam M

机构信息

Institut für Medizinische Mikrobiologie und Hygiene, Johannes Gutenberg-Universítdt Mainz, Germany.

出版信息

Trends Microbiol. 1996 Oct;4(10):375-82. doi: 10.1016/0966-842X(96)10061-5.

DOI:10.1016/0966-842X(96)10061-5

PMID:8899962

Abstract

Some Clostridium species produce ABX-type protein cytotoxins of high molecular weight. These toxins constitute the group of large clostridial cytotoxins (LCTs), which have homologous protein sequences, exert glycosyltransferase activity and modify GTP-binding proteins of the Ras-superfamily. These characteristics render the LCTs valuable tools for developmental and cell biologists.

摘要

一些梭菌属物种会产生高分子量的ABX型蛋白质细胞毒素。这些毒素构成了大梭菌细胞毒素（LCTs）组，它们具有同源蛋白质序列，发挥糖基转移酶活性并修饰Ras超家族的GTP结合蛋白。这些特性使LCTs成为发育生物学家和细胞生物学家的宝贵工具。