Romero-Cabello R, Robert L, Muñoz-García R, Tanaka J
Departamento de Microbiología y Parasitología, Facultad de Medicina, UNAM.
Rev Latinoam Microbiol. 1995 Oct-Dec;37(4):315-23.
An open, randomized study was carried out with 100 children to compare the efficacy and security of albendazole and metronidazole to eradicate Giardia lamblia. We included 100 patients in primary school age with giardiasis confirmed by parasitoscopic test who had not received treatment during the 2 previous months. A complete clinical study was performed. By using an aleatory code, the children were distributed in 2 groups: A and B. The clinical data was corroborated and the following tests were made: cell blood count, blood chemistry, direct and concentrated coproparasitoscopic study. Both groups were given an antiparasite treatment consisting of albendazole for group A or metronidazole for group B. Clinical, parasitological and blood controls were conducted before, during and after the treatment. A therapeutic efficacy of 94% and 98% for group A and B, respectively, was found. We concluded that albendazole and metronidazole are equally effective in a 5 days treatment period, but some undesirable effects may occur with metronidazole.
一项针对100名儿童的开放性随机研究开展，以比较阿苯达唑和甲硝唑根除蓝氏贾第鞭毛虫的疗效和安全性。我们纳入了100名小学年龄的患者，他们经镜检确诊为贾第虫病，且在前两个月内未接受过治疗。进行了全面的临床研究。通过随机编码，将儿童分为两组：A组和B组。对临床数据进行了核实，并进行了以下检查：血细胞计数、血液化学、直接和浓缩粪便寄生虫镜检研究。两组均接受抗寄生虫治疗，A组给予阿苯达唑，B组给予甲硝唑。在治疗前、治疗期间和治疗后进行临床、寄生虫学和血液检查。结果发现A组和B组的治疗有效率分别为94%和98%。我们得出结论，在5天的治疗期内，阿苯达唑和甲硝唑同样有效，但甲硝唑可能会出现一些不良反应。
