阿苯达唑与甲硝唑治疗伊朗伊斯兰共和国贾第虫病患者的疗效比较
Albendazole versus metronidazole in the treatment of patients with giardiasis in the Islamic Republic of Iran.
作者信息
Alizadeh A, Ranjbar M, Kashani K M, Taheri M M, Bodaghi M
机构信息
Research Centre for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Islamic Republic of Iran.
出版信息
East Mediterr Health J. 2006 Sep;12(5):548-54.
We examined the therapeutic effects of albendazole compared to metronidazole in 120 patients with giardiasis in Hamdan. Patients were randomized to receive albendazole (400 mg, once daily for 5 days) or metronidazole (250 mg, 3 times a day for 5 days). Demographic data of the patients, results of stool examination for Giardia trophozoites before and after treatment, and drug side-effects were recorded. After treatment 6 (10.0%) of the albendazole group had trophozoites compared with 14 (23.3%) of metronidazole group (P < 0.05). Patients in the albendazole group had fewer side-effects while 43.3% of the metronidazole group experienced a metallic taste and 35.0% experienced loss of appetite. Albendazole is an easy, safe and effective treatment for giardiasis.
我们在哈姆丹对120例贾第虫病患者研究了阿苯达唑与甲硝唑相比的治疗效果。患者被随机分为接受阿苯达唑（400毫克，每日一次，共5天）或甲硝唑（250毫克，每日3次，共5天）治疗。记录患者的人口统计学数据、治疗前后粪便中贾第虫滋养体的检查结果以及药物副作用。治疗后，阿苯达唑组有6例（10.0%）存在滋养体，而甲硝唑组有14例（23.3%）（P<0.05）。阿苯达唑组患者的副作用较少，而甲硝唑组有43.3%的患者出现金属味，35.0%的患者出现食欲不振。阿苯达唑是一种治疗贾第虫病简便、安全且有效的方法。
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