Martino M, Morabito F, Messina G, Irrera G, Pucci G, Iacopino P
Dipartimento di Emato-Oncologia, Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria, Italy.
Haematologica. 1996 Jan-Feb;81(1):59-61.
The amount of transfused dimethyl sulfoxide (DMSO) is indicated as the major cause of the cryoprotectant-related toxicity in autologous stem cell recipients, with a high incidence of major cardiac side effects. In this study we tried to discover whether fractionated infusion of the total graft volume could prevent the DMSO-related major cardiovascular side effects. We conclude that continuous cardiac monitoring during and after fractionated infusions of DMSO-containing graft documented no major arrhythmias, with only seven episodes of asymptomatic sinus bradycardia.
输注的二甲基亚砜（DMSO）量被认为是自体干细胞接受者中与冷冻保护剂相关毒性的主要原因，主要心脏副作用的发生率很高。在本研究中，我们试图探究将移植物总体积进行分次输注是否可以预防与DMSO相关的主要心血管副作用。我们得出结论，在分次输注含DMSO的移植物期间及之后进行连续心脏监测，未发现重大心律失常，仅出现7次无症状窦性心动过缓。
