（14β，15β，16β，17α）-和（14β，15α，16α，17α）-1,3,5（10）-雌甾三烯-2,3,14,15,16,17-己醇的合成，这两种化合物可能是稻上-田村内源性类洋地黄因子的候选物，以及它们的活性。
Syntheses of (14 beta,15 beta,16 beta,17 alpha)- and (14 beta,15 alpha,16 alpha,17 alpha)-1,3,5(10)-estratriene-2,3,14,15,16,17- hexaols, possible candidates for the Inagami--Tamura endogenous digitalis-like factor, and their activity.
作者信息
Sakakibara M, Uchida A O
机构信息
Pharmaceutical Research Laboratories, Kirin Brewery Co., Ltd., Gunma, Japan.
出版信息
Biosci Biotechnol Biochem. 1996 Mar;60(3):405-10. doi: 10.1271/bbb.60.405.
PMID:8901096
Abstract
Structures are proposed for the Inagami-Tamura endogenous digitalis-like factor (EDLF), and two possible candidates, (14 beta,15 beta,16 beta,17 alpha)- and (14 beta,15 alpha,16 alpha,17 alpha)-2,3,14,15,16,17-hexahydroxy-1,3,5(10)-estratrienes, were synthesized. Both compounds were potent in inducing a contractile response in isolated rat aorta and guinea pig left atrium.
摘要
已提出稻上-田村内源性类洋地黄因子（EDLF）的结构，并合成了两种可能的候选物，即(14β,15β,16β,17α)-和(14β,15α,16α,17α)-2,3,14,15,16,17-六羟基-1,3,5(10)-雌三烯。这两种化合物在诱导离体大鼠主动脉和豚鼠左心房的收缩反应方面都具有效力。
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