（14β，17α）-14-羟基雌二醇和（14β，17α）-2,14-二羟基雌二醇的合成及其活性
Syntheses of (14 beta,17 alpha)-14-hydroxy- and (14 beta,17 alpha)-2, 14-dihydroxyestradiols and their activities.
作者信息
Sakakibara M, Uchida A O
机构信息
Pharmaceutical Research Laboratories, Kirin Brewery Co., Ltd., Gunma, Japan.
出版信息
Biosci Biotechnol Biochem. 1996 Mar;60(3):411-4.
PMID:8901097
Abstract
Structure 1 is proposed for the Inagami-Tamura endogenous digitalis-like factor (EDLF), and (14 beta,17 alpha)-14-hydroxy- and (14 beta,17 alpha)-2,14-dihydroxyestradiols (2 and 3) were synthesized as models for studies on 1. The latter compound was remarkably potent in inducing a contractile response in isolated rat aorta and guinea pig left atrium.
摘要
结构1被认为是稻上-田村内源性洋地黄样因子（EDLF）的结构，并且合成了（14β，17α）-14-羟基和（14β，17α）-2,14-二羟基雌二醇（2和3）作为对结构1进行研究的模型。后一种化合物在诱导离体大鼠主动脉和豚鼠左心房的收缩反应方面具有显著效力。
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