乳铁蛋白和乳铁素对人多形核白细胞白细胞介素8释放的影响。

Effects of lactoferrin and lactoferricin on the release of interleukin 8 from human polymorphonuclear leukocytes.

作者信息

Shinoda I, Takase M, Fukuwatari Y, Shimamura S, Köller M, König W

机构信息

Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd., Kanagawa, Japan.

出版信息

Biosci Biotechnol Biochem. 1996 Mar;60(3):521-3. doi: 10.1271/bbb.60.521.

DOI:10.1271/bbb.60.521

PMID:8901116

Abstract

Human or bovine lactoferrin (LF) and lactoferricin (LFcin), a peptide derived from the N-terminal region of LF, each have the ability to stimulate the release of neutrophil-activating polypeptide interleukin 8 (IL-8) from human polymorphonuclear leukocytes (neutrophils, PMNs). This finding suggests that LF and LFcin may both function as immunomediators for activating the host defense system. A basic peptide, protamine, exerted the same effect as that of LF and LFcin, suggesting the importance of the basic nature of LF and LFcin in acting as an inducer of IL-8 release from PMNs.

摘要

人乳铁蛋白（LF）或牛乳铁蛋白以及乳铁传递蛋白肽（LFcin，一种源自LF N端区域的肽）均有能力刺激人多形核白细胞（中性粒细胞，PMN）释放中性粒细胞激活多肽白细胞介素8（IL-8）。这一发现表明，LF和LFcin可能都作为免疫介质发挥作用，激活宿主防御系统。一种碱性肽鱼精蛋白发挥了与LF和LFcin相同的作用，这表明LF和LFcin的碱性性质在作为PMN释放IL-8的诱导剂方面具有重要性。