Wang Xiao, Wang Xiumin, Hao Ya, Teng Da, Wang Jianhua
a Key Laboratory of Feed Biotechnology, Ministry of Agriculture, Beijing 100081, P.R. China.
b Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, P.R. China.
Biochem Cell Biol. 2017 Feb;95(1):162-170. doi: 10.1139/bcb-2016-0073. Epub 2016 Oct 7.
Lactoferrin (Lf), a multifunctional glycoprotein, is an important antimicrobial and immune regulatory protein present in neutrophils and most exocrine secretions of mammals. Lactoferricin (Lfcin) is located in the N-terminal region of this protein. In this review, the current state of research into Lf and Lfcin in China is described. Searching with HistCite software in Web Sci located 118 papers published by Chinese researchers from 2011-2015, making China one of the top 3 producers of Lf research and development in the world. The biological functions of Lf and Lfcin are discussed, including antibacterial, antiviral, antifungal, anticarcinogenic, and anti-inflammatory activities; targeted drug delivery, induction of neurocyte, osteoblast, and tenocyte growth, and possible mechanisms of action. The preparation and heterologous expression of Lf in animals, bacteria, and yeast are discussed in detail. Five Lf-related food additive factories and 9 Lf-related health food production companies are certified by the China Food and Drug Administration (CFDA). The latest progress in the generation of transgenic livestock in China, the safety of the use of transgenic animals, and future prospects for the uses of Lf and Lfcin are also covered.
乳铁蛋白（Lf）是一种多功能糖蛋白，是存在于哺乳动物中性粒细胞和大多数外分泌分泌物中的一种重要的抗菌和免疫调节蛋白。乳铁蛋白肽（Lfcin）位于该蛋白的N端区域。在这篇综述中，描述了中国对Lf和Lfcin的研究现状。使用HistCite软件在Web Sci中搜索发现，2011年至2015年中国研究人员发表了118篇论文，使中国成为世界上Lf研发的前三大产出国之一。讨论了Lf和Lfcin的生物学功能，包括抗菌、抗病毒、抗真菌、抗癌和抗炎活性；靶向药物递送、诱导神经细胞、成骨细胞和肌腱细胞生长以及可能的作用机制。详细讨论了Lf在动物、细菌和酵母中的制备和异源表达。五家与Lf相关的食品添加剂工厂和九家与Lf相关的保健食品生产公司获得了中国食品药品监督管理总局（CFDA）的认证。还涵盖了中国转基因家畜培育的最新进展、转基因动物使用的安全性以及Lf和Lfcin使用的未来前景。
