Miyadai K, Ohsumi J, Yoshimura C, Kawashima I, Ito Y
Biomedical Research Laboratories, Sankyo Co. Ltd., Tokyo, Japan.
Biosci Biotechnol Biochem. 1996 Mar;60(3):541-2. doi: 10.1271/bbb.60.541.
Biological activities of the carboxy-terminal (C-terminal) deletion mutants of human interleukin-11 (IL-11) were analyzed. Removal of only 1 amino-acid residue (leucine) from the C-terminus caused nearly an 80% loss of its biological activity. This shows the importance of C-terminus of human IL-11 in terms of conserving the biological activity.
对人白细胞介素-11（IL-11）羧基末端（C末端）缺失突变体的生物学活性进行了分析。仅从C末端去除1个氨基酸残基（亮氨酸）就导致其生物学活性丧失近80%。这表明人IL-11的C末端在保持生物学活性方面的重要性。
