Russeva V, Mihailova D
Department of Chemistry, Faculty of Pharmacy, Sofia, Bulgaria.
Arzneimittelforschung. 1996 Mar;46(3):288-92.
Modelling of the binding of two non-steroidal anti-inflammatory drugs, indometacin (CAS 53-86-1) and diclofenac sodium (CAS 15307-79-6) to the molecule of human serum albumin is presented. The models are based on the data obtained using difference spectroscopic technique. Speculations were made concerning the structural properties of the drugs and albumin molecules as well as the type of chemical interactions taking part in the drug-albumin binding. The proposed approach represents a more detailed investigation on the mechanism of drug-protein interactions.
本文介绍了两种非甾体抗炎药吲哚美辛（CAS 53 - 86 - 1）和双氯芬酸钠（CAS 15307 - 79 - 6）与人血清白蛋白分子结合的模型。这些模型基于使用差示光谱技术获得的数据。对药物和白蛋白分子的结构特性以及参与药物 - 白蛋白结合的化学相互作用类型进行了推测。所提出的方法代表了对药物 - 蛋白质相互作用机制更详细的研究。
